P-742: Serum anti-mullerian hormone and inhibin B levels at ovulation triggering day can reflect ovarian response in IVF cycles?

Abstract

Although basal serum levels of anti-mullerian hormone (AMH) and inhibin B have been reported to be good predictors of ovarian response in patients undergoing IVF, there were few reports concerning the significance of these markers measured at late follicular phase during ovarian hyperstimulation in IVF cycles. The aim of this study was to investigate whether serum levels of AMH and inhibin B at ovulation triggering day reflect ovarian response in IVF cycles. Prospective analysis. Thirty-three IVF cycles from twenty-eight patients were enrolled between April and December 2005. The mean age of female was 33.4±3.8 years old; the mean duration of infertility was 4.6±2.4 years. Infertility factors were tubal (n=14), unexplained (n=9), male (n=3), and endometriosis (n=2). Ovarian hyperstimulation was performed using rhFSH + urinary hMG (n=19), rhFSH only (n=10), urinary hMG only (n=3), and CC+rhFSH (n=1). The mean dose of gonadotropin administered was 26.1±7.9 ampoules. The pituitary was suppressed by GnRH agonist (n=4) or antagonist (n=29) and ovulation was triggered by recombinant hCG. Blood samples were drawn on the day of hCG administration. Serum AMH levels did not correlate with the number of oocytes, however, inhibin B and estradiol levels showed a significant positive correlation with the number of oocytes (r=0.5916, P=0.0003 ; r=0.6254, P=0.0001). AMH levels positively correlated with inhibin B (r=0.4702, P=0.0058) and estradiol levels (r=0.4341, P=0.0116). The number of oocytes obtained after ovarian hyperstimulation had a significant positive correlation with serum inhibin B and estradiol levels at ovulation triggering day, but not with serum AMH levels.