Abstract
The best protocol of controlled ovarian hyperstimulation (COH) to be associated to intrauterine insemination (IUI) remains to be determined. The current task is to establish a protocol that may reduce the risk of multiple births without hampering the rate of success of the procedure. A debated issue in this context is related to the usefulness of gonadotropin-releasing hormone (GnRH) antagonists. The role of this drug in COH-IUI cycles has been previously investigated in three randomised studies but results were conflicting.
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