Abstract
During the early human life, somatic cells differentiate and specialize to certain functions through intense epigenetic modifications. The gametes’ genome also undergoes these epigenetic modifications, however, they are then later erased (except gonad specific imprinting) contributing to the preservation of their longevity and the potential to produce a new individual. Gametes in the female gonad present an age dependent decrease of quality and related decline of female fertility is also well described.
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