P-703: Human oocytes express Gs G-protein and the G-protein-coupled receptor Gpr3, key components in the maintenance of meiotic arrest in mouse oocytes

Abstract

Although researchers have begun to elucidate the mechanisms that regulate meiosis in some mammals, relatively little is known about meiotic arrest and resumption in response to LH in the human oocyte. It has previously been shown that the Gs-linked, G-protein-coupled receptor GPR3 plays a role in the maintenance of meiotic arrest in the mouse oocyte by maintaining high intracellular levels of cyclic AMP. Previous studies have shown that oocytes from Gpr3 knockout mice resume meiosis within antral follicles independent of an increase in LH.