Abstract
Tissue-specific expression of the calreticulin (CALR) gene in the brain gray matter in late-adolescence and early adulthood coincides with the expression of the psychoses phenotypes. We report functional mutations at −48, −205 and −220 in the promoter of the human CALR gene that co-occur with the spectrum of psychoses including schizophrenia, schizoaffective disorder, and bipolar disorder type I. None of those mutations have been detected in the control population (p
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