P-702 - Down-tuning of the calreticulin gene in the process of human evolution

Abstract

Tissue-specific expression of the calreticulin (CALR) gene in the brain gray matter in late-adolescence and early adulthood coincides with the expression of the psychoses phenotypes. We report functional mutations at −48, −205 and −220 in the promoter of the human CALR gene that co-occur with the spectrum of psychoses including schizophrenia, schizoaffective disorder, and bipolar disorder type I. None of those mutations have been detected in the control population (p