P.7.d.011 Association between duration of untreated psychosis and functionality within family environment in early-onset first episode psychosis

Abstract

variance has been performed by group, age and IQ. Age, IQ and severity (CGI, C-GAS) effects were analyzed by Pearson’s correlation; single emotions by repeated measures. Statistical significance required two-tailed p 0.05. Results: Drug-free ADHD and ASD children were significantly slower than TDCs in both FR in FR (RTc: ASD p= 0.01, ADHD p< 0.001; RTe: ASD e ADHD p< 0.001) and IFE (RTc: ASD p= 0.001, ADHD p= 0.022; RTe: ASD p= 0.004). ASD were also slower compared with TDCs in MFE4 (RTc p = 0.039, RTe p = 0.05). Both drug-free ADHD and ASD appeared less accurate than TDCs in MFE4 (ASD p= 0.007, ADHD p= 0.002) and IFE (ASD p= 0.004, ADHD p= 0.005), but not in FR. When processing ‘surprise’, both the ASD and ADHD group exhibited longer RTc compared to TDCs (ASD p< 0.001, ADHD p= 0.018). MPH treatment induced a significant improvement in facial recognition abilities both in speed (RTc: p = 0.023) and accuracy (p< 0.001); increased accuracy has also been observed in IFE (p = 0.004) and MFE tasks (p< 0.001), especially in ‘Happiness’ recognition (p< 0.001). Discussion: The results suggest that specific information processing deficits during face recognition and identification of facial emotions stimuli are present in both ADHD and ASD compared to TDC, with some differences between them. These data highlight the utility, in both ADHD and ASD children, of specific neuropsychological tasks to better characterize strengths and difficulties in their cognitive/affective functioning, in order to develop specific and efficient treatment strategies. Preliminary results suggest that MPH facilitates emotion recognition, whilst not influencing processing speed, confirming recent evidence of MPH regulatory effect not only on inhibitory fronto–striatal circuitry but even its effect in attenuating abnormal activity within affective circuits involved in emotional processing [3].