P-632 Evaluation of low AMH levels in young women

Abstract

Abstract Study question The primary objective was to evaluate impact of a low AMH level on the live birth rate in a population of young women IVF/ICSI . Summary answer Low AMH level in young women in FIV/ICSI is not expected to have an impact on the live birth. What is known already AMH is an important criterion for defining ovarian reserve. The majority of studies have shown that the AMH level in the general population is not correlated with the chances of spontaneous pregnancy. The management remains a challenge and must be individualized taking into account the new quantitative and qualitative criteria to be defined (POSEIDON classification). Finally, we know that the pregnancy rate is correlated to the rate of euploid embryos, and that the rate is higher before 35 years of age. Study design, size, duration In this single-center retrospective study from January 2015 to December 2020, 1824 IVF/ICSI attempts were analyzed. We analyzed the live birth rate according to 2 categories of young women matched by AMH level. Participants/materials, setting, methods We analyzed the live birth rate according to 2 categories of young women managed in IVF/ICSI protocol. A first group was ≤30 years old and a second group was between 31 and 35 years old. Then, we matched each of these groups to an AMH level, AMH<1ng/mL and AMH ≥1ng/mL. We analyzed the live birth rate of 4 groups of young women. Main results and the role of chance 1824 IVF/ICSI attempts were analyzed in this study. We have 539 women under 30 years of age and 1285 women between 31 and 35 years of age. For women aged ≤30 years, the group with AMH<1ng/mL had a non-statistically significant live birth rate compared to those with AMH≥1ng/mL (31% vs 32.7% p = 1). For women aged 31-35 years, the group with AMH<1ng/mL, has a statistically significant lower live birth rate compared to those with AMH≥1ng/mL (14.5% vs 29.3% p = 0.001). Limitations, reasons for caution The main limitation of our study is the few number of patients. Wider implications of the findings This study tries to demonstrate that low AMH levels in young women do not predict a poor IVF/ICSI success rate. Conclusions should not be drawn too quickly for low AMH in this population. However, the threshold AMH level is still debated in the studies and should be further adjusted. Trial registration number not applicable