P 6 Eye movement disturbances are associated with regional brain volume loss in neurodegenerative Parkinsonism

Abstract

Background Assessment of eye movement control in Parkinson’s disease (PD), multisystematrophy (MSA), and progressive supranuclear palsy (PSP) shows disease-related oculomotor alterations ( Pinkhardt and Kassubek, 2011 ). Volumetric 3D MRI analysisis a tool of growing relevance inthe differential diagnosis in neurodegenerative Parkinsonism ( Huppertz et al., 2016 ). Objective To investigate the association between impaired eye movement control and regional volume loss in PD, MSA, and PSP patients. Methods Video-oculographic data (EyeLink®) and high resolution 3-dimensional T1-weighted MRI images from 39 PD, 32 PSP, 18 MSA patients, and 24 matched healthy control subjects wereincluded in the analysis. Atlas based volumetry (ABV) was used to investigate for regional volumetric alterations ( Huppertz et al., 2016 ). Results In PD, saccadic intrusions were commonly observed as a measure for executive control (pppp). Conclusions The worse the characteristically impaired eye movement parameter in PD, MSA and PSP, the more severe was the disease-specific regional volume loss.