Abstract
Glassy Polymeric Carbon (GPC), a biocompatible material, has been proposed for drug encapsulation and delivery. We have shown that a wide range of available porosity in the bulk material can be obtained by careful attention to the method of production and heat treatment of GPC. In addition, ion bombardment is shown to modify the available surface porosity and permeability. These surface characteristics are determined by choice of specie, fluence and energy of the bombarding ions. Together with appropriate drug concentration gradients within the capsule, the capsule can be made to deliver an initial dose rate either higher or lower than the steady state value. The effective surface area, as well as the availability of the pores, can be modified by oxygen or gold ion bombardment either to increase or decrease.
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