Abstract
An attempt is made to interpret the time-course of three kinds of neuronal responses (monophasic, polyphasic and biphasic responses) to microelectrophoretically applied drugs. A simple diffusional model is used in order to account for concentration changes at the neuronal receptor sites. It is suggested that the time-course of the simple monophasic response may closely follow the concentration curve. These suggestions are supported by experimental evidence concerning the reflection of ejecting and retaining currents and of the mobility of drug ions in the time-course of the neuronal response. Polyphasic responses may reflect the distribution of receptors over the surface of a large neurone, or on a principal neurone and an excitatory interneurone. Biphasic responses may be the result of the activation of receptors located on a principal neurone and on an inhibitory interneurone. An alternative explanation for biphasic responses could be that both inhibitory and excitatory receptors are activated on the same neurone. Reversal of monophasic responses (occurring spontaneously or in the presence of an antagonist) suggests that an opposite type of receptor may be masked on some neurones. The selective blockade of masked inhibitory receptors may be the basis for the potentiating effects of some antagonists.
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