Abstract
The research of molecular mechanisms of obesity formation in adolescence is topical. The aim of this research was to study lipid peroxidation and antioxidant system changes in Mongoloid-patients with obesity and hepatosis. The study included 17 adolescence boys with exogenous constitutional obesity and hepatosis and 20 healthy individuals, Mongoloids living in Eastern Siberia. All patients underwent examination which included collection of anamnestic and clinical data, analysis of anthropometric parameters and nutritional status assessment. Spectrophotometric and fluorometric methods were used. Increased levels of primary lipid peroxidation products - diene conjugates (1.5 times) and increased concentration of secondary products - ketodienes and conjugated trienes (3.38 times) in patients with obesity and hepatosis were registered. In the antioxidant defense system were noted reduced values of α-tocopherol (1.27 times), retinol (1.45 times) in comparison with control. Exogenous-constitutional obesity with hepatosis in Mongoloid-patients was exposed to more oxidative stress than adolescent boys with normal weight.
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