Abstract
HOX genes are highly evolutionarily conserved regulators of embryonic development. HOXA10 continues to regulate differentiation of the adult reproductive tract and mammary gland in response to sex steroids. HOXA10 estrogen response elements ERE1 and ERE2 were recently characterized and are differentially expressed in response to 17B-estradiol (E2) or diethylstilbestrol (DES) in uterine cells. Here we demonstrate that estrogen responsive HOXA10 expression is not only ligand specific but cell type specific.
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