P-41648991-91 - Giant cell lesions manifesting as underlying primary hyperparathyroidism

Abstract

<h3>Aims and Objective</h3> To evaluate clinical features, prevalence, biochemical findings and treatment modality of giant cell lesions associated with primary hyperparathyroidism in the maxillofacial region. <h3>Materials and Methods</h3> All histopathologically diagnosed cases of giant cell lesions in the maxillofacial region were evaluated retrospectively from eight year old data base in the department of oral and maxillofacial surgery at Govt Dental College Srinagar. Giant cell lesions associated with primary hyperparathyroidism were studied with respect to serum calcium, phosphate, alkaline phosphate and parathormone and other clinical features. The cases were studied and co -related after the correction of primary hyperparathyroidism. <h3>Result</h3> Histopathologically 51 proven giant cell lesions were evaluated and 7 cases were found associated with primary hyperparathyroidism. Two cases had simultaneous maxillary and mandibular involvement. The patients had high values of alkaline phosphate and parathormone on follow up. All 7 patients of primary hyperparathyroidism had significant reduction of lytic bone lesions after parathyroidectomy eliminating the need for surgical intervention for bony lesions. <h3>Conclusion</h3> The prevalence of primary hyperparathyroidism associated giant cell lesions is 5.9%. and is therefore rare. Sometimes the giant cell lesions associated with primary hyperparathyroidism may be the only manifestation and so appropriate work up of patients clinically,rdiographically and biochemically is important to rule out such lesions which are otherwise similar to other giant cell lesions like central giant cell granuloma.