P-405: The FSHR C566T mutation and the INHa G769A mutation are rare in Chinese women with POF

Abstract

Premature ovarian failure (POF) is a condition causing amenorrhea, hypoestrogenism and elevated gonadotropins before the age of 40 years. POF is not uncommon, considering its 1% incidence rate. This syndrome is very heterogeneous and its etiologies remain unknown in most cases. Genetic disorder is the main cause of POF. Follicular stimulating hormone (FSH) and inhibin (INH) play important roles in folliculogenesis and fertility in humans. FSH receptor (FSHR) C566T mutation was first reported in a Finnish population, but it was not found to be associated with POF in other populations.