P-373 T657C SYCP3 mutation increases the risk of recurrent miscarriage: a meta-analysis

Abstract

Abstract Study question Is the carrying the unfavorable SYCP3 mutation T657C polymorphism increase risk of recurrent miscarriage? Summary answer We showed that carrying the T657C polymorphism of the SYCP3 mutation of the synaptonemal complex contributes among the genetic causes of recurrent miscarriage. What is known already Recurrent pregnancy loss (RPL) is one of the most common reproductive problems. RPL occurs in 0.5-3% of married couples. The causes of RNP are varied. One of the reasons may be the carriage of an unfavorable polymorphism T657C mutation SYCP3. However, previous studies show conflicting results on mutation rates in women with RPL. Study design, size, duration Recurrent pregnancy loss (RPL) is one of the most common reproductive problems. RPL occurs in 0.5-3% of married couples. The causes of RNP are varied. One of the reasons may be the carriage of an unfavorable polymorphism T657C mutation SYCP3. However, previous studies show conflicting results on mutation rates in women with RPL. Participants/materials, setting, methods We performed a meta-analysis to determine the strength of the evidence supporting the contribution of carrying the unfavorable SYCP3 mutation T657C polymorphism to recurrent miscarriage. We searched 2 databases (PubMed, Google Scholar) for studies reporting the impact of T657C SYCP3 mutation on recurrent miscarriage up to 20 October 2021. We built a funnel plot to assess the presence of publication bias.The odd ratio (OR) and its 95% confidence interval (95% CI) served as pooled results. Main results and the role of chance The review included four studies with 1161 patients: 529 patients with RPL and 632 healthy women. Compared with the control group of healthy women, the risk of recurrent miscarriage increased by 2.37 times with the T657C SYCP3 mutation (RR 2.37, 95% CI 1.39, 4.01, P <0.001). Limitations, reasons for caution The review included studies on different ethnic groups, patients were of different ages, which could affect the results of the studies. Wider implications of the findings Determining whether women with recurrent miscarriage belong to the carriers of the unfavorable polymorphism T657C of the SYCP3 mutation in the population will help in accumulating knowledge and understanding the processes of pregnancy loss. Trial registration number not avaliable