P-359 - An independent risk factor for cardiovascular diseases in diabetic nephropathy; Homocysteine

Abstract

Homocysteine (Hcy) is an important amino acid that is associated with many pathological reactions that increase in serum concentration due to increased oxidative stress in the body. Diabetic nephropathy (DN), which has been emphasized more recently, is one of the critical pathological reactions that take place in the body. Moreover, DN is an important cause of morbidity and mortality, especially in diabetes and is one of the leading causes of end stage Kidney disease (ESKD). Hcy also emerges as an important risk factor for atherosclerotic disease in ESKD patients. In this study, it was aimed to determine the changes in Hcy levels of individuals with DN and to evaluate these changes in terms of oxidant balance and cardiovascular risk. In our study, 22 patients with DN and 25 healthy subjects'sera were used. The HPLC system was used to determine Hcy levels in the serum. When Hcy levels were compared between the study groups, Hcy levels in DN patients were statistically significantly higher than control group. The relationship between diabetic complications and patients can be explained by the toxic effect of Hcy directly on the endothelium. The increase in HCY level is a contributing factor to the cardiovascular events among the most common causes of death, especially in DN.