Abstract
Activation of multiple signaling pathways of the Epidermal Growth Factor Receptor (EGFR), the RAS-RAF or the PI3K-PTEN-AKT pathways, is considered the most common carcinogenic mechanisms in colorectal cancer (CRC). Mutated RAS genes and BRAF gene encode constitutive activation of the Ras/Raf/MAPK Signaling Pathway, even in the absence of growth factor signaling. The result is a sustained proliferation signal within the cell. In our study, we aimed to report the frequency of RAS/RAF mutations in Moroccan colorectal cancer (CRC) patients.
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