Abstract
Colorectal cancer liver metastases (CLMs) occur in 25%-30% of CRC patients which represent a heterogeneous cohort of patients based on the extent of the disease and the eligibility for resection. Resectable liver-confined metastasis is the best scenario as surgery can offer cure with a 5-year survival of about 40%. The caveat is that only 25% of CLMs are initially resectable so preoperative treatment could confer conversion of unresectable and borderline CLMs into respectability. Practical speaking, there are no guidelines that help clinical decision-making in the management of CLMs with regards to resectability criteria and best systemic treatment to be used.
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