P-35 * THE CHANGES OF BLOOD GLUCOSE CONTROL AND LIPID PROFILES AFTER SHORT-TERM SMOKING CESSATION IN HEALTHY MALES

Abstract

The changes in blood glucose control, lipid profiles, and insulin resistance-associated hormones both before and after 2-months of smoking cessation in Korean male smokers were examined. Smoking abstinence was evaluated through self-report and urine cotinine levels. 12 individuals who succeeded in quitting smoking were analyzed. Fasting values of glucose and insulin were used to estimate the b-cell activity and insulin resistance was evaluated using the Homeostasis Model Assessment (HOMA) and Quantitative Insulin Sensitivity Check Index (QUICKI). The data showed that the subjects had a significant increase in weight, body mass index and fasting plasma glucose levels after smoking cessation. The HOMA-Insulin Resistance (HOMA-IR) and The HOMA b-cell function (HOMA-b) increased significantly. The QUICKI showed a significant decrease. In addition, the low-density lipoprotein cholesterol levels decreased significantly; however, changes in the high-density lipoprotein cholesterol, the triglyceride and total cholesterol levels were not significant. The results of this study showed during the initial stage of smoking cessation, insulin resistance increased and insulin sensitivity decreased due to elevated body weight and fat composition. Moreover, the likely explanation for this finding is the compensation of beta cells for insulin resistance.