P-344 Long-term outcomes after combined chemoradiation therapy of locally advanced rectal cancer, complicated by fistula formation

Abstract

Introduction: Locally advanced rectal (LARC) cancer with invasion to adjacent organs is usually detected in 5 – 22% of primary patients. Rectovesical, rectovaginal and external fistulas are present in 7-9% of these patients. Neoadjuvant chemoradiation therapy (NCRT) might cause a great benefit for tumor downstaging, downsizing and disease-free survival, but vast majority of cases presence of a fistula remains a contraindication for such procedure. The role of NCRT in cases of LARC with fistula formation isn't developed, leaving many actual questions unsolved