Abstract
Within the past decade, several studies have tested capecitabin as a substitute for 5-FU in the treatment of localised squamous cell carcinoma of the anal canal (SCCAC) and reported similar clinical response rates, making capecitabin an acceptable and more convenient alternative to infusional 5-FU. However, the differences in efficacy between capecitabine and 5-FU in CRT with simultaneous integrated boost-intensity modulated radiation therapy (SIB-IMRT) for locally SCCAC are not documented. We performed this retrospective study to compare the response of capecitabine and 5-FU in survival and toxicity terms in patients with locally SCCAC treated with concurrent SIB-IMRT.
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