P-33 - The comparison of vitamin E and vitamin C levels in type 2 diabetic patients under monotherapy

Abstract

Background In Type 2 Diabetes Mellitus (T2DM) high blood glucose levels increases oxidative stress. Metformin is a first-choice antidiabetic drug for T2DM patients to lower blood glucose levels, oxidative stress and provide better lipid profiles. Objectives This study was planned to detect antioxidant vitamin (E and C) levels in T2DM patients at the time of diagnose (t=0) and after 6 months of monotherapy (t=180). Methods A total of 17 patients were recruited. Blood samples (10 ml) were taken when patients were first diagnosed with T2DM and after six months of Metformin usage. We also had an age and sex matched control group. Results Vitamin C levels of T2DM patients t=0 was significantly lower than the healthy controls (p=0.000). At t= 180, Vitamin C levels of patients almost reached the Vitamin C levels of controls and this elevation was found to be significant between t= 180 and t= 0 (p= 0.001). On the other hand, Vitamin E levels of healthy controls and T2DM patients t= 0 were not significantly different. At t= 180, Vitamin E levels of T2DM patients were detected as significantly lower than healthy controls (p=0.267). Conclusion Our data suggests that there is an inverse correlation between Vitamin C and Vitamin E levels of T2DM patients under monotherapy for 6 months period