P-314 PlasmaShotting: a new method of treating “thin” endometrium

Abstract

Abstract Study question Is a new method of subendometrial platelet-rich plasma (PRP) injection (PlasmaShotting) effective in patients with “thin” endometrium? Summary answer PlasmaShotting showed higher efficiency in the group of patients with “thin” endometrium compared to conventional intrauterine infusion of platelet-rich plasma What is known already The problem of “thin” endometrium is one of the urgent challenges of modern reproductive medicine. In patients suffering from this condition, there is a decrease in the pregnancy rate and an increase in miscarriage rates. “Thin” endometrium is less than 7 mm according to ultrasound. To correct this condition, many methods have been proposed: hormone replacement therapy with high doses of estrogens, aspirin, GnRH agonists, vitamin E, pentoxifylline, sildenafil, intrauterine infusion of colony-stimulating factors (G-CSF) and PRP, but none of the proposed methods has shown enough effectiveness. Study design, size, duration To evaluate the effectiveness of PlasmaShotting we organized a study that included 72 people. Inclusion criteria were age less than 40 years, endometrial thickness less than 6.5 mm on days 8-10 of hormone replacement therapy, and 3 or more unsuccessful embryo transfers of excellent quality embryos before. Participants/materials, setting, methods The patients were divided into 2 groups: Group 1 (23 patients) underwent hysteroscopy with submucosal injections of platelet-rich plasma (PRP - PlasmaShotting) on days 10-12 of the cycle. Group 2 (49 patients) underwent intrauterine infusion of platelet-rich plasma (PRP) on days 10-12 of the cycle Main results and the role of chance The clinical pregnancy rate in group 1 was 47.8% (n = 11), and in group 2 was 34.6% (n = 17). The live births rate in group 1 was 34.7% (n = 8), and in group 2 was 20.4% (n = 10). The miscarriage rate was in group 1 was 13.1% (n = 3), and in group 2 was 14.2% (n = 7) Limitations, reasons for caution The research on the effectiveness of PlasmaShotting should be continued Wider implications of the findings PlasmaShotting as a new method of treating “thin” endometrium can be used in patients who can't achieve pregnancy Trial registration number not applicable