P.3.f.003 Gender differences in psychosis with co-occurring substance use disorder

Abstract

The mean age of onset of the illness was 24.8±6.1 years. The average PANSS total score and ASEX total score were respectively 51.8±12.8 and 17.7±5.6. The average equivalent dose chlorpromazine was 475±279 mg/day. Sexual dysfunction was present in 55% of outpatients with schizophrenia (total score 19 or ASEX Item 5 or 3 items 4). We didn’t found relationship between sexual dysfunction and sociodemographic characteristics except gender. Female had higher ASEX total score (p = 0.002). Arousal and orgasm disorders were more frequent in women (p = 0.005 and p = 0.001). For clinical factors, patients with continuous evolution of schizophrenia had higher ASEX total score (p = 0.049). There was a relationship between the ASEX total score and dose of treatment (r = 0.36, p = 0.001) and with the severity of symptoms (r = 0.31, p = 0.005). Conclusions: More than half of our outpatients with schizophrenia had sexual dysfunction. Women had more sexual dysfunctions. Sexual dysfunction is correlated to symptoms severity, continuous evolution and dose treatment.