P-298 The use of propensity score matching to assess the effectiveness of the endometrial receptivity analysis in patients with recurrent implantation failure

Abstract

Abstract Study question The purpose of this study was to investigate the effect of ERA on pregnancy outcomes in patients with RIF. Summary answer The results of the study showed no significant difference in pregnancy outcomes in patients who received ERA compared to those who did not. What is known already One potential cause of implantation failure is abnormal endometrial receptivity, and how to objectively evaluate endometrial receptivity has been a matter of great concern. Endometrial receptivity analysis (ERA), a microarray-based test that assesses endometrial gene expression, may be valuable in predicting endometrial receptivity, but whether ERA improves pregnancy outcomes in patients with recurrent implantation failure (RIF) is currently controversial. Study design, size, duration We performed a retrospective cohort study analysis for a population of patients with RIF undergoing frozen embryo transfer (FET) cycles in the reproductive center of the Third Affiliated Hospital of Zhengzhou University from January 2019 to December 2022(n = 1598). Participants/materials, setting, methods FET cycles with personalized embryo transfer (PET) under ERA guidance were included in the ERA group (n = 43); after using propensity score matching (PSM), a total of 120 FET cycles were included as a control group. Pregnancy outcomes were compared between the two groups. Further, the relationship between the number of previous implant failures and the rate of implant window displacement was discussed. The factors affecting the window of implantation (WOI) displacement were also assessed. Main results and the role of chance There was no statistically significant difference in embryo implantation rate, clinical pregnancy rate, spontaneous abortion rate, and live birth rate between the ERA group and the matched control patients (P > 0.05). Limitations, reasons for caution Our study is a non-large sample size retrospective study, because ERA is not a routine test in assisted reproductive technology clinics. Wider implications of the findings In our study, PET did not significantly improve pregnancy outcomes in patients with RIF, no significant differences in pregnancy outcomes were found between patients with moderate and severe RIF after PET, and no underlying etiology affecting WOI displacement was identified. Trial registration number not applicable