Abstract
EGFR antibodies are efficient in the treatment of patients with RAS wild type metastatic colorectal cancer (mCRC). However, 25% of those patients resist to this therapy. This could be explained by other genetic alterations. Hedgehog (Hh) signaling pathway was described in the development and transition to metastatic stages. The aim of this study is to investigate the expression of Gli1, transcription factor of Hh signaling pathway, and PDGFRα, target gene of Hh signaling pathway, in colorectal adenocarcinoma as compared to normal mucosa and to assess their correlation with clinicopathological features and molecular RAS status.
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