Abstract
The present study addressed the role of accumbal mu- and kappa-opioid receptors in ethanol intake using male AA rats trained to drink 10% (v/v) ethanol in a limited access paradigm. The mu-opioid receptor antagonist CTOP (0.3, 1, or 3 ug per side), the mu-opioid receptor agonist DAMGO (0.03, 0.1, or 0.3 ug), the kappa-opioid receptor agonist U50488H (0.3, 1, or 3 ug), and the kappa-opioid receptor antagonists JDTic (15 ug) and nor-binaltorphimine (3 ug) were injected bilaterally into the nucleus accumbens shell. In another experiment, rats received a single subcutaneous injection of JDTic (10 mg/kg) and the long-term effects of the treatment on ethanol intake were monitored. CTOP, DAMGO and U50488H failed to alter ethanol intake significantly, though CTOP (0.3 and 1 ug) tended to increase and DAMGO (0.1 ug) to decrease ethanol intake. There was a tendency for decreased ethanol intake 72 h after accumbal JDTic, while systemic JDTic decreased ethanol intake at 48 h and 96 h. These results support the notion that central mu- and kappa-opioid receptors participate in the control of voluntary ethanol intake. They also suggest that accumbal kappa-opioid receptors may have a more prominent role in ethanol intake than previously assumed.
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