Abstract
retrospectively. Non-responsiveness to IVIG was defined as persistent fever (37.5oC over 1 day) after finishing IVIG. This criterion was met in 38 patients (40%), who were all treated with additional IVIG. WBC, CRP, and sodium concentrations were determined before and within half a day after initial IVIG. Generally, the measurement of these laboratory data has been possible at any time. Results: Multivariate logistic regression analysis selected increased WBC count (p < 0.01), increased CRP (p < 0.05), and low sodium concentration (<135mEq/L, p < 0.01) just after initial IVIG, as independent predictors of non-responsiveness to low-dose IVIG. The criteria for at least one of the three predictors were considered to be useful for detecting non-responsiveness to initial low-dose IVIG for acute KD (Sensitivity = 89%, Specificity = 60%). Conclusion: Using our simple predictive models, we can select non-responder to low-dose IVIG treatment, which decrease a total dosage of IVIG in patients with acute KD.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
