Abstract

Pancreatic ductal adenocarcinoma (PDAC) represents the majority of diagnosed pancreatic cancers and its mortality rates are well above 90%. This bleak scenario is mostly due to its very difficult early diagnosis, scarce surgical treatability, high relapse rate and poor response to systemic and targeted therapies. Apparently, an imbalance between male and female incidence of PDAC could suggest some sort of “protective mechanism” in women against the onset of this neoplasia, possibly played by estrogen receptors.

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