Abstract
The tumor microenvironment (TME) determines therapeutic response, and its modulation can help to overcome therapeutic resistance. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine whose overexpression is associated with tumor aggressiveness, metastasis, and disease progression. Due to its ubiquitous nature, MIF is considered an unsuitable target for therapeutic intervention. However, a disease-related isoform of MIF, oxidized MIF (oxMIF), is specifically present in solid tumor tissue including colorectal and pancreatic cancer.
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Schedule a callMore From: Annals of oncology : official journal of the European Society for Medical Oncology
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