P-249 Clinico-epidemiological management of gastric adenocarcinoma. A retrospective study of 105 cases

Abstract

The incidence of gastric cancer varies widely by country and population. The gastric cancer is the fourth most frequently occurring malignancy and the most common cause of death from cancer worldwide. 80-90 % of patients are ultimately diagnosed at an advanced stage. Surgical resection of the local disease is the gold standard therapy; chemotherapy and radiotherapy have improved loco- regional control rates and distance. The prognosis is poor with a survival rate at 5 years not exceeding 15% for all stages combined. We retrospectively analyzed 105 patients with gastric carcinoma admitted to the medical oncology department between January 2018 and December 2020. All of our patients was from western Algeria. The mean age was 59 years, with range (27-83 years), 55,23% male and 44,76% female, sex ratio was 1.23. Most patients had a good performance status (0-1) in 76%. Weight loss was found in 14% of patients. Risk factors: tobacco (32,3 %), alcohol tobacco (6 %) gastric ulcer ( 5,7 % ). Abdominal pain was the most frequent symptom (95%), followed by vomiting (73%) and anemia in 43 % of cases. 39 % localized in antrum, 33 % fundus, 33 % antro-pyloric. The histological diagnosis was confirmed in all cases with 100 % of adenocarcinoma from endoscopy. HER2:3+ found in 9,5 %. According to TNM classification, the majority of patients were in stage III (56 %), stage IV (33 %), only 2% were in stage I. 88% of patients received chemotherapy, neo-adjuvant chemotherapy in 57%, adjuvant in 42%, palliative in 53%. The response was stability in 40%, RC in 1,61%, RP 11 %, progression 39%. 64,7% ongoing surgery. Gastric carcinoma is rare in Algeria. It is still diagnosed in an advanced stage in relatively young patients. A screening program at national scale should be investigated to improve prognosis of this cancer.