Abstract
The consensus molecular subtypes (CMS) of colon cancer integrated the results of several different subtyping efforts and led to the definition of four distinct groups with clinical relevance (CMS1-4). The connection between tumor morphology and molecular subtypes has been previously described qualitatively and quantitatively. Moreover, it has been suggested that variability in tumor sampling strategies would lead to less reproducible subtype classifications. To better understand the sources of heterogeneity and for stabilizing the CMS classifier, we performed a morphology-directed tumor sampling for RNA extraction and compared the predicted CMS with whole-tumor results.
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