Abstract
In mammals, embryonic development is a continuous phenomenon of multistep gene expression modulated by transcription factors. Oct-4 determines cell fate with highly conserved DNA sequences and its expression is down regulated in trophectoderm. The mechanism underlying this lineage-specific repression is not understood. Oct-4 is down regulated by all-trans retinoid acids (tRA) via the nuclear retinoid receptor in murine embryonal carcinoma cells. This study examines for similar down regulation effects in murine morulae and human blastocysts.
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