Abstract
Colorectal cancer (CRC) is the leading cause of cancer-related death worldwide. Rectal cancer constitutes around one-third of all CRCs. The current standard of care of patients with locally advanced rectal cancer is neoadjuvant radio/chemo-radiotherapy; however, treatment differs substantially across countries. Novel markers are required to optimize the treatment. Extramural vascular invasion (EMVI) is a well-established magnetic resonance imaging (MRI)-based negative prognostic marker. Systemic inflammatory response markers such as lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR) or platelet-to-lymphocyte ratio (PLR) are novel blood-based prognostic markers in many cancers, including CRC.
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