Abstract
Hepatocellular carcinoma (HCC) has an extremely unfavorable prognosis and lack of effective medication therapy. The excessive production of reactive oxygen species is the main cause of its initiation and progression, therefore the use of antioxidants could be a promising treatment. Biocompatible pristine C 60 fullerenes are powerful antioxidants, non-toxic and able to be accumulated in the liver. Therefore, their effects on HepG2 cells and liver state on rat HCC models were aimed to be discovered.
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