Abstract
Thymidine incorporation proliferation assays to whole bovine P 2 protein and its 58–81 and 14–25 synthetic peptides were performed on blood mononuclear cells from ten patients with Guillain-Barré syndrome (GBS), six patients with chronic idiopathic demyelinating polyradiculoneuropathy (CIDP), and age and sex matched normal subjects. The only patients whose cells showed any response were two out of four with very early GBS. One responded to P 2 and both synthetic peptides. One responded to P 2 but to neither peptide. The results support a role for cell mediated immunity to P 2 protein in some patients with Guillain-Barré syndrome.
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