P.2.011 GluA1 and its Postsynaptic density protein 95 (PSD-95)/Discs large/Zonula occludens-1 (PDZ)-interaction: a role in experience-dependent behavioural plasticity in the forced swim test

Abstract

treatment with neither L-DOPA nor L-DOPA/sarizotan induced any significant behavioural sensitisation. Chronic treatment with L-DOPA and L-DOPA/sarizotan induced AIMs in both lines of rats. However, FRL rats treated with L-DOPA spent more time in AIMs compared to FSL rats. Moreover, co-administration with sarizotan reduced significantly L-DOPA-induced AIMs in FRL, but not in FSL rats. In situ hybridisation analysis showed that treatment with L-DOPA and L-DOPA/sarizotan significantly increased c-fos mRNA levels in the lesioned side as compared to the nonlesioned side of saline treated FRL and FSL rats. Interestingly, c-fos mRNA level in FSL group after chronic L-DOPA treatment was significantly lower than in FRL group receiving the same treatment. Moreover, co-administration with sarizotan reduced significantly L-DOPA-induced c-fos in FRL, but not in FSL, rats. The results suggest that parkinsonian animals with distinct depressive-like phenotypes react differently to PD treatments in terms of dyskinetic behaviour and striatal neuronal-like activity.