Abstract
The use of proton pump inhibitors (PPIs) has been associated with inferior oncological outcomes in breast, gastric and colorectal cancers. Such findings are supposedly due to a pharmacokinetic interaction between PPIs and capecitabine, where a PPI-induced increase in gastric pH leads to reduced absorption of capecitabine. We aimed to investigate whether such interaction would influence pathological response to chemoradiation with capecitabine as a substitute for 5FU.
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