P 19. Modulating Attentional Control with non-Invasive Brain Stimulation and its Effect on Prospective Memory Performance in Older Adults

Abstract

Background. Prospective memory refers to the ability to remember to carry out future intentions at a certain time, following a specific event, or upon the completion of another task [1]. Normal prospective memory functions are particularly important in older age (e.g., remember to take your medication) as they maintain functional independence and well-being [2], [3]. Attentional control (i.e., focusing on relevant information while ignoring other information) has been discussed to be of key relevance for proper prospective memory functions [4]. In the current study, we will apply non-invasive brain stimulation on areas, known to be associated with both attentional control and prospective memory to find out whether this would lead to performance changes in either of the two or both. Method. In a double blind, sham-controlled, and parallel group study, we will include n=105 healthy older volunteers (60-75 years of age; 50% female). They will be randomly assigned to one of six stimulation groups (or sham). We will use high-definition transcranial direct current stimulation (Soterix medical). Participants will receive either cathodal or anodal stimulation of the left inferior frontal, right inferior frontal, or right superior parietal gyrus for 20 min (1mA) during which they will complete an attentional control task as well as a prospective memory task. We will also assess performance prior to and following stimulation. Outlook. The results of our study will help to clarify the role of attentional control in older adults“ prospective memory performance. With our findings we may help to create new interventions to counteract age-related decline of prospective memory.