Abstract
Colorectal cancer (CRC) is a common cancer, both nationally and globally. Platelets had a proinflammatory action, recruiting neutrophils and macrophages, driving vessel-wall inflammation, and influencing lymphocyte function, NK cells, and B cells. Sizeable changes in the number and ratio of peripheral immune cells, including monocytes, lymphocytes, neutrophils, platelets, and tumor-educated platelets, have been observed, with both favorable and unfavorable consequences in solid tumors. Little is written about the predictive value of these inflammatory response changes for the metastatic colorectal cancer (MCRC) treatment outcome and their clinical application.
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