P-178 - Oxidative stress in blood cells of men and women with Alzheimer's and Parkinson's diseases

Abstract

Oxidative stress plays an important role in the development of neurodegenerative diseases. Accordingly, higher levels of oxidative stress have been detected in brain and CFL from these patients. Recent studies suggest that these pathologies show systemic disturbances. The aim of the study was to measure antioxidant enzyme activities (glutathione reductase (GR) and glutathione peroxidase (GPx)), as well as malondialdehyde (MDA) in whole blood from individuals with mild cognitive impairment (MCI), Alzheimer's disease (AD) and Parkinson's disease (PD) (10 women and 10 men in each group). The values obtained were compared to those of an age-matched control group (15 women and 15 men). MCI, AD and PK groups showed lower GPx (both genders) and GR (men only) activities compared to controls. Regarding MDA levels, only the MCI and AD groups showed higher levels compared to the control group in both men and women, suggesting that this marker can be specific for AD. The fact that MCI individuals already show higher MDA levels than controls, together with the easy obtainability of the sample type used (whole blood), suggests that this parameter can be used as a marker of prodromal AD in the clinical setting.