Abstract
Background: Intracerebral hemorrhage (ICH) is caused by the rupture of a blood vessel, resulting in bleeding into the brain. This type of stroke accounts for 12-15% of all strokes and is the most fatal type of stroke (40% mortality rate). ICH stroke presents a greater burden to survivors as 90% of ICH survivors have some degree of disability. Because of the poor patient outcomes, there is a clear need for identifying new treatments as well as establishing the efficacy of existing treatments. Methods: Using previously described techniques we aim to establish a mouse model of ICH at the University of Saskatchewan. We observed them at a 1- 24-, 48- and 72hr mark post-stroke and scored for neurological deficits. Results: We currently have conducted 23 model trials. We have data on mice at 1-, 24, and 72 hr post-stroke. We have observed and begun to analyze a lesion area that can be seen in H&E stained sections, and further assessed with FTIR, and synchrotron modalities. Conclusions: We have analyzed several of the specimens with FTIR imaging and synchrotron analysis with the Canadian Light Source. We have preliminary results of the progression of metabolites in the hematoma and peri-hematoma zone of the ICH.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
