P.160 The impact of antipsychotics on metabolic parameters in the treatment of schizophrenia: A systematic review and meta-analysis of placebo-controlled trials

Abstract

A promising approach to repair significant organ and tissue damages is to incorporate tissue-engineered scaffolds which can closely mimic the heterogenous three-dimensional structure, physical and biological properties of extracellular matrix (ECM), and function of the native tissue. Nevertheless, regaining natural organ functionality remains a prime challenge in organ regeneration due to the lack of nanofibrous architectures, unique physical properties (e.g., electrical conductivity), mechanical properties of synthetic or natural biomaterials to create functional tissue grafts. Carbon-based nanomaterials such as graphene and carbon nanotubes have drawn an incomparable interest in the development of flexible electronic devices, supercapacitors, biosensors, and actuators for biomedical applications owing to their excellent mechanical and electrical properties and interesting nanoscale features such as large surface area and micropatterning capability. Endowed with nanoscale features, carbon-based structures can provide nanofibrous architectures and tunable physical properties such as porosity and degradability to compensate for the deficiencies of microporous scaffolds in providing tissue-specific engineered ECM. Recently, integration of such nanomaterials in bioengineered tissues has unveiled a new approach toward creating functional biomimetic tissues and organs. In this chapter, we have highlighted some of the most recent progresses in developing functional engineered tissues, namely, in the fields of cardiac, neural, bone, and muscle tissue regeneration. Lastly, we discuss prospective applications of hybrid carbon-based engineered tissues in organ reparation and regeneration.