P-160 Potentiated Angiogenetic Effects of LOX-1 via Induction of Vascular Endothelial Growth Factor in Ischemic Leg

Abstract

periodic acceleration alleviates myocardial ischemia as a result of increased coronary and peripheral vasodilatory reserve. Methods: Twenty one anginal patients [66±10 (SD) years] were randomly assigned to remain sedentary (Sedentary group: SE group, n = 9) or undergo 20 passive exercise sessions with the motion platform for 4 weeks (Periodic acceleration group: PA group, n = 10). Periodic acceleration was applied at 2 to 3Hz and approximately ±2.2m/sec2 for 45 min. We repeated the symptom-limited exercise test using the standard Bruce protocol and adenosine sestamibi myocardial scintigraphy. Results: Treatment with periodic acceleration increased the extent of improvement in exercise time until 0.1mV ST depression from pre-treatment to post-treatment (PA group vs. SE group = 2.1±1.1 vs. 0.4±0.9 minutes, p < 0.05), and the extent of improvement in double product at 0.1mV ST depression (PA group vs. SE group = 1,950±1,101mmHgbeats/min vs. 875±1,378mmHg-beats/min, p < 0.05). After treatment with periodic acceleration, the extent of improvement in severity score of the scintigraphy during adenosine infusion was significantly higher in PA group compared with SE group (6.1±4.7 to 1.4±2.8, p < 0.05), indicating that size of ischemic and hibernating myocardium became smaller with treatment. The extent of decrease in left ventricular end-diastolic volume index were significantly higher in PA group compared with SE group (15.1±17.4 to 0.1±2.0ml/m2, p < 0.05), with a significantly augmented extent of improvement in left ventricular ejection fraction (4.3±5.1 to 0.1±2.1%, p < 0.05). Conclusions: Novel treatment with an application of repeated periodic acceleration improves myocardial ischemia and left ventricular function in anginal patients through central and peripheral effects.