P.144: Recipient Age and Outcomes Following Simultaneous Pancreas-Kidney Transplantation in the New Millennium: Single Center Experience and Review of the Literature

Abstract

Introduction: The influence of recipient age on outcomes following simultaneous pancreas-kidney transplantation (SPKT) in the modern era is uncertain. Methods: We retrospectively studied 255 patients undergoing SPKT from 11/01 to 8/20. Recipients were stratified according to age group: age <30 years (n=16); age 30–39 years (n=91); age 40–49 years (n=86), and age ≥ 50 years (n=62 [24.3%], including 9 patients ≥60 years of age). Results: Three-month and one-year outcomes were comparable. The eight-year patient survival rate was lowest in the oldest age group (47.6% versus 78% in the 3 younger groups combined, p<0.001). However, eight-year kidney and pancreas graft survival rates were comparable in the youngest and oldest age groups combined (36.5% and 32.7%, respectively), but inferior to those in the middle 2 groups combined (62% and 50%, respectively, both p<0.05). Death-censored kidney and pancreas graft survival rates increased from youngest to oldest recipient age category because of a higher incidence of death with functioning grafts (22.6% in oldest group compared to 8.3% in the 3 younger groups combined, p=0.005). Conclusions: Recipient age did not appear to significantly influence early outcomes following SPKT. Late outcomes are similar in younger and older recipients, but inferior to the middle 2 age groups.