P-120 Prospective observational study monitoring circulating tumor DNA in resectable colorectal cancer patients undergoing radical surgery: GALAXY study in CIRCULATE-Japan (trial in progress)

H Yukami,S Mishima,D Kotani,E Oki,H Taniguchi,Y Nakamura,T Kato,I Takemasa,T Yamanaka,H Shirasu,K Sawada,H Ebi,A Aleshin,P Billings,M Rabinowitz,M Mori,T Yoshino

doi:10.1016/j.annonc.2020.04.202

P-120 Prospective observational study monitoring circulating tumor DNA in resectable colorectal cancer patients undergoing radical surgery: GALAXY study in CIRCULATE-Japan (trial in progress)

H Yukami, S Mishima + Show 15 more

Open Access

https://doi.org/10.1016/j.annonc.2020.04.202

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Journal: Annals of oncology : official journal of the European Society for Medical Oncology	Publication Date: Jul 1, 2020
Citations: 6	License type: publisher-specific-oa

Affiliation: National Cancer Center Hospital East, Kyushu University, Osaka National Hospital, Sapporo Medical University, Yokohama City University, Shizuoka Cancer Center, Aichi Cancer Center, Natera (United States)

#Early Detection Of Recurrence #Circulating Tumor DNA + Show 8 more

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Abstract

Adjuvant chemotherapy has reduced the risk of tumor recurrence and improved survival in patients with resected colorectal cancer (CRC). Early clinical utility of circulating tumor DNA (ctDNA) at the time points of pre- and post-surgery has been reported across various solid tumor subtypes including CRC. Analysis of ctDNA status could be utilized as a predictor of risk stratification for recurrence, optimization of adjuvant chemotherapy, and early detection of recurrence. We present here the study design of an ongoing trial.

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