P-12 * THE STUDY OF TREATMENT RESPONSE IN DEPRESSIVE PATIENTS WITH ALCOHOL USE DISORDERS BY USING HAM-D

Abstract

Introduction. It is known that high rate of comorbidity exists between mood disorders and alcohol use disorders. In this study, we assessed the change of the HAM-D 17-items from baseline to study endpoint to evaluate treatment-resistant depression symptoms in those patients with alcohol use disorders. Method. Fifty-eight participants with depression were divided into 2 groups: non-alcohol use disorder (NAUD) group (n = 36) and alcohol use disorder (AUD) group (n = 22) according to AUDIT score (NAUD: below 12, AUD: over 12). The effect of medication on depressive symptoms was monitored at 2, 4, 8, 12 weeks using the HAM-D. Results. The baseline score of HAM-D sleep item was higher in AUD than in NAUD. AUD showed significantly less improvement in the HAM-D sleep items from baseline to endpoint compared to NAUD. Benzodiazepine medications (equivalent to greater than 10mg of diazepam) resulted in significant baseline to endpoint improvement in insomnia early item of HAM-D in NAUD. On the other hand, there was no significant improvement in HAM-D sleep items after treatment in AUD. Conclusion. These results suggest that alcohol use disorder may negatively affect depression treatment outcomes not only in the overall response rate but also in the efficacy of benzodiazepines for sleep disturbance.