P-12 Long intergenic non-protein coding RNA 1094 regulates the progression of gastric cancer

Abstract

Gastric cancer (GC) is one of the most common cancers globally. The role of Long intergenic non-coding RNA 01094 (LINC01094) in GC tumorigenesis is still unknown. This study aimed to explore the function and potential mechanism of LINC01094 in GC. LncRNA and MicroRNA expressions were measured via qRT-PCR. MTT and Transwell assays were used to investigate cell proliferation and migration ability. In the TCGA database, LINC01094 was more highly expressed in GC tissues compared with para-tumor tissues, and elevated LINC01094 expression was associated with late TNM stage and poor survival rate. Cell functional experiments indicated that LINC01094 knockdown inhibits GC cells growth and migration. Furthermore, LINC01094 acts as a competing endogenous RNA to bind miR-330-3p and miR-577 in GC cells. LINC01094 promoted the progression of GC though the miR-330-3p and miR-577 regulatory axis, which might provide a new therapeutic perspective for GC.