Abstract
Introduction Various psychomotor dysfunction are observed in opioid-addicted patients. Therefore it is important to determine the effect of psychoactive substance administered therapeutically in substitution therapy. Aims This study aims to assess the impact of a single therapeutic dose of methadone on hand-eye coordination and motor learning in opioid-addicted patients treated in substitution therapy. Methods Was examined 72 patients and 60 healthy subjects. The Pursuit Rotor Task (PRT) was used. The PRT was conducted twice: before and about 1 hour after administration of methadone in the opioid-addicted patients and at an about 1 hour interval in the control group. The study was performed for both the dominant and non-dominant hand. Results The statistical significantly (p Conclusions Administration of a single therapeutic dose of methadone in opioid-addicted patients may reduce high amplitude tremor and improve hand-eye coordination.
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