P.112 Location pattern of recurrence of WHO Grade 1 Meningiomas

Abstract

Background: Meningiomas can lead to significant morbidity and mortality and have recurrence potential despite their benign classification. The precise location of the recurrence has not been delineated. The objective of this study was to determine any spatial clustering of recurrence for surgically treated Grade 1 meningiomas. Methods: Patients diagnosed with Grade 1 meningiomas and treated with surgical resection with recurrence were reviewed. Patient demographics, presentation, extent of resection, time to recurrence, and location were established by medical records. Outcomes were the time to recurrence and location relative to the original surgical bed. Results: Among the 42 cases that met the study inclusion criteria, 12 were male and 30 were female. The mean age at treatment was 49.7 years, and the mean years until recurrence was 5.2 years. 33 (68.8%) tumours recurred locally, 12 (25.0%) recurred at the periphery (<1cm of the surgical bed), and 3 (6.3%) recurred distal to the resection site. Conclusions: A sizeable portion of cases may benefit from therapy directed beyond the resection margin. It may be more successful to prevent recurrence in these patients by performing a more aggressive resection of the dural attachment surrounding the tumour and/or focusing adjuvant therapy on the area surrounding the resection cavity.